β-Nicotinamide Mononucleotide CAS: 1094-61-7

β-Nicotinamide mononucleotide (NMN) ni a lo lati ṣe iwadi awọn idii abuda laarin awọn aptamers RNA ati awọn ilana imuṣiṣẹ ribozyme pẹlu β-nicotinamide mononucleotide (β-NMN) -awọn ajẹkù RNA ti a mu ṣiṣẹ.NMN jẹ nucleotide ti o wa lati ribose ati nicotinamide.Niacinamide (nicotinamide,) jẹ itọsẹ ti Vitamin B3, ti a tun mọ ni niacin.) Gẹgẹbi iṣaju biochemical ti NAD +, o le wulo ni idena ti pellagra.
β-Nicotinamide mononucleotide jẹ agbedemeji ninu biosynthesis ti nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) ṣe itọda ifunmọ ti nicotinamide pẹlu 5-phosphoribosyl-1-pyrophosphate lati ṣe ipilẹṣẹ β-NMN, eyiti o yipada si NAD + nipasẹ β-NMN adenyltransferase.At 50-100 β-N ti lo μM. NAD biosynthesis ati yomijade hisulini ti o ni glukosi ni awoṣe Nampt +/- Asin ti arun ti iṣelọpọ, ti n ṣe afihan ipa kan fun Nampt ni iṣẹ sẹẹli β.