Mirabegron CAS: 223673-61-8 Olupese Olupese

Mirabegron jẹ fun itọju iyara, igbohunsafẹfẹ ito, ati ito ito ailabajẹ ti o ni nkan ṣe pẹlu àpòòtọ overactive (OAB).Mirabegron jẹ iṣelọpọ nipasẹ sisọpọ 4-nitrophenethyl amine si (R) -2-hydroxy-2-phenylacetic acid.Abajade amide ti dinku si amine.Ẹgbẹ nitro ti dinku lẹhinna abajade jẹ pọ si 2- (2-aminothiazol-4-yl) acetic acid lati fun mirabegron.

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Mirabgron jẹ agonist β3-adrenoceptor ti n ṣiṣẹ lọwọlọwọ lọwọlọwọ ni idagbasoke nipasẹ Astellas Pharma fun itọju ti àpòòtọ apọju (OAB).Oogun naa jẹ antagonist EC50 nanomolar lodi si awọn igbelewọn biochemical β3-AR eniyan pẹlu yiyan ti o dara lori b1- ati β2-ARs.Mirabegron ṣe afihan ilana aramada kan nipa titọkasi β3-AR fun isinmi apo-itọpa lati ṣe iranlọwọ lati ṣakoso awọn aami aisan OAB bii iyara ito ti o pọ si ati igbohunsafẹfẹ ati ailagbara iyara.Bibẹẹkọ, mirabegron jẹ oludena cytochrome P450 2D6, ati pe o gbe ibakcdun kan fun ibaraenisepo oogun-oògùn pẹlu iṣakoso igbakọọkan ti awọn sobusitireti cytochrome P450 2D6 miiran.

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Tiwqn	C21H24N4O2S
Ayẹwo	99%
Ifarahan	Funfun to Bia Yellow lulú
CAS No.	223673-61-8
Iṣakojọpọ	25KG
Igbesi aye selifu	ọdun meji 2
Ibi ipamọ	Itaja ni itura ati ki o gbẹ agbegbe
Ijẹrisi	ISO.