Clascoterone CAS: 19608-29-8 Olupese Olupese

Clascoterone ti wa ni idagbasoke bi ipara ti o wa ni oke nipasẹ Cassiopea fun awọn ailera awọ-ara ti o gbẹkẹle androgen.Clascoterone (cortexolone 17α-propionate, CB-03-01) jẹ antagonist aramada ti awọn olugba androgen.O sopọ si awọn olugba androgen pẹlu isunmọ giga.Nipa dije pẹlu androgens fun sisopọ si awọn olugba androgen, clascoterone ṣiṣẹ nipa didi awọn ami ifihan agbara androgen receptor cascades ti o ṣe agbega pathogenesis irorẹ, gẹgẹbi isunmọ ẹṣẹ sebaceous, iṣelọpọ sebum pupọ, ati awọn ipa ọna iredodo.Ni Oṣu Kẹjọ ọdun 2020, FDA fọwọsi clascoterone fun itọju agbegbe akọkọ-ni-kilasi ti irorẹ (irorẹ vulgaris) ninu awọn alaisan ọkunrin ati obinrin ti ọdun 12 ati ju bẹẹ lọ.Clascoterone tun n ṣe iwadii bi itọju aramada fun alopecia androgenetic.