Candesartana Cilexetila CAS: 145040-37-5

Candesartan cilexetil jẹ oogun ti o lagbara, ṣiṣe pipẹ, ati yiyan angiotensin II iru 1 antagonist olugba AT1, candesartan.O ti wa ni iyara hydrolyzed si candesartan lakoko gbigba ifun inu.Lẹhin hydrolysis ti candesartan cilexetil si candesartan lakoko gbigba ifun-inu, candesartan yiyan ti njijadu pẹlu angiotensin II fun isopọmọ ti angiotensin II subtype receptor 1 AT1 ni iṣan dan ti iṣan, didi angiotensin II-mediated vasoconstriction ati inducing vasodilatation.Ni afikun, antagonism ti AT1 ninu ẹṣẹ adrenal ṣe idinamọ angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex;iṣuu soda ati iyọkuro omi pọ si, atẹle nipa idinku iwọn pilasima ati titẹ ẹjẹ.